SCIENTIFIC PUBLICATIONS

SCIENTIFIC PUBLICATIONS

Monoglyceride Lipase as a Drug Target: At the Crossroads of Arachidonic Acid Metabolism and Endocannabinoid Signaling
Gernot F. Grabner, Robert Zimmermann, Rudolf Schicho, Ulrike Taschler
Pharmacology & Therapeutics – 02/14/2017


Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrom
Larisa V. Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A Kohnz, Francisco Madamba, Gabriel M. Simon, Natalia E. Kleschevnikova, Daniel K. Nomura, R. Alan B. Ezekowitz, Alexander M. Kleschevnikov
PLOS – 12/04/2014


Endocannabinoid Hydrolysis Generates Brain Prostaglandins that Promote Neuroinflammation
Nomura, D.K., Morrison, B.E., Blankman, J.L., Long, J.Z., Kinsey, S.G., Marcondes, M.C., Ward, A.M., Hahn, Y.K., Lichtman, A.H., Conti, B., Cravatt, B.F.
Science – 10/20/2011


Reversible Competitive alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics
Ezzili, C., Mileni, M., McGlinchey, N., Long, J. Z., Kinsey, S. G., Hochstatter, D. G., Stevens, R. C., Lichtman, A. H., Cravatt, B. F., Bilsky, E. J. & Boger, D. L.
J Med Chem. – 04/28/2011


Click-Generated Triazole Ureas As Ultrapotent, In Vivo-Active Serine Hydrolase Inhibitors
Adibekian, A., Martin, B.R., Wang, C., Hsu, K.L., Bachovchin, D.A., Niessen, S., Hoover, H., Cravatt, B.F.
Nat. Chem. Biol. – 03/30/2011


A Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis
Chang, J.W., Nomura, D.K., Cravatt, B.F.
Chem. Biol. – 02/08/2011


Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., Fu, G. C. & Cravatt, B. F.
Proc Natl Acad Sci U S A – 01/13/2011


Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening
Bachovchin, D. A., Ji, T., Li, W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S. & Cravatt, B. F.
Proc Natl Acad Sci U S A – 08/10/2010


Selective Blockade of 2-Arachidonoylglycerol Hydrolysis Produces Cannabinoid Behavioral Effects
Long, J.Z., Li, W., Booker, L., Burston, J.J., Kinsey, S.G., Schlosburg, J.E., Pavon, F.J., Serrano, A.M., Selley, D.E., Parsons, L.H., Lichtman, A.H., Cravatt, B.F.
Nat. Chem. Biol. – 01/05/2009


Discovering potent and selective reversible inhibitors of enzymes in complex proteomes
D. Leung, C. Hardouin, D. L. Boger, and B. F. Cravatt
Nat. Biotechnol. – 03/28/2003


Structural Adaptations in a Membrane Enzyme that Terminates Endocannabinoid Signaling
Bracey, M.H., Hansen, M., Masuda, K., Stevens, R.C., Cravatt, B.F.
Science – 11/29/2002


Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides
Cravatt, B. F.; Giang, D. K.; Mayfield, S. P.; Boger, D. L.; Lerner, R. A.; Gilula, N. B
Nature – 11/07/1996


REVIEWS:

The Pharmacological Landscape and Therapeutic Potential of Serine Hydrolase
Bachovchin, D.A. Cravatt, B.F.
Nat. Rev. Drug Discover – 01/03/2012