Scientific Papers

Endocannabinoid Hydrolysis Generates Brain Prostaglandins that Promote Neuroinflammation

Nomura, D.K., Morrison, B.E., Blankman, J.L., Long, J.Z., Kinsey, S.G., Marcondes, M.C., Ward, A.M., Hahn, Y.K., Lichtman, A.H., Conti, B., Cravatt, B.F.

Science - 10/20/2011
 
Reversible Competitive alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics

Ezzili, C., Mileni, M., McGlinchey, N., Long, J. Z., Kinsey, S. G., Hochstatter, D. G., Stevens, R. C., Lichtman, A. H., Cravatt, B. F., Bilsky, E. J. & Boger, D. L.

J Med Chem. - 04/28/2011
 
Click-Generated Triazole Ureas As Ultrapotent, In Vivo-Active Serine Hydrolase Inhibitors

Adibekian, A., Martin, B.R., Wang, C., Hsu, K.L., Bachovchin, D.A., Niessen, S., Hoover, H., Cravatt, B.F.

Nat. Chem. Biol. - 03/30/2011
 
A Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis

Chang, J.W., Nomura, D.K., Cravatt, B.F.

Chem. Biol. - 02/08/2011
 
Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., Fu, G. C. & Cravatt, B. F.

Proc Natl Acad Sci U S A - 01/13/2011
 
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

Bachovchin, D. A., Ji, T., Li, W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S. & Cravatt, B. F.

Proc Natl Acad Sci U S A - 08/10/2010
 
Selective Blockade of 2-Arachidonoylglycerol Hydrolysis Produces Cannabinoid Behavioral Effects

Long, J.Z., Li, W., Booker, L., Burston, J.J., Kinsey, S.G., Schlosburg, J.E., Pavon, F.J., Serrano, A.M., Selley, D.E., Parsons, L.H., Lichtman, A.H., Cravatt, B.F.

Nat. Chem. Biol. - 01/05/2009
 
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

D. Leung, C. Hardouin, D. L. Boger, and B. F. Cravatt

Nat. Biotechnol. - 03/28/2003
 
Structural Adaptations in a Membrane Enzyme that Terminates Endocannabinoid Signaling

Bracey, M.H., Hansen, M., Masuda, K., Stevens, R.C., Cravatt, B.F.

Science - 11/29/2002
 
Molecular characterization of an enzyme that degrades neuromodulatory fatty acid amides

Cravatt, B. F.; Giang, D. K.; Mayfield, S. P.; Boger, D. L.; Lerner, R. A.; Gilula, N. B

Nature - 11/07/1996
 

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